Tianeptine sulfate dosage. Tapering off tianeptine sulfate should be done gradually under medical supervision to minimize withdrawal symptoms like insomnia. Read about the safety, side effects, and controversy here. Oct 19, 2021 · The neuribiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation. Nov 8, 2024 · Discover comprehensive details about Tianeptine, including its pronunciation, uses, dosage instructions, indications, and guidelines on how and when to take it or avoid it. Tianeptine is not approved by the U. We would like to show you a description here but the site won’t allow us. The sulfate form from Ceretropic is longer lasting with smoother effects. [10] Tianeptine also displays significant anxiolytic properties and is useful in treating a Jul 14, 2024 · Decades before it became known as "gas station heroin," tianeptine was prescribed to treat depression in dozens of countries. 5mg, 3x a day as well as tianeptine sulfate 25mg/50mg once a day. Any higher gives me the jitters. Jun 16, 2025 · The U. I've noticed that eating a small to medium sized meal about 4 hours after a sulfate dose brings out the feeling quite a bit. Abrupt discontinuation can worsen sleep disturbances and may affect blood pressure control, especially in patients with hypertension. Food and Drug Administration is warning the public about a drug rising in popularity, commonly referred to as "gas station heroin. As with other antidepressants, tianeptine is contraindicated in patients taking monoamine oxidase inhibitors. It is sold online and in stores—including in some gas stations and vape shops. Food and Drug Administration issued a stark warning against products that contain tianeptine, which are marketed as an atypical antidepressant in many countries. It has not been approved by the FDA, but there has been an increase in people using tianeptine in the US. In theory, tianeptine's neuroprotective action makes it a potential life-extension drug for the wider "euthymic" population. It has no FDA approved use in the U. Conclusions Tianeptine sulfate is believed to present some diferences versus tianeptine sodium: it is sold only through the Internet without prescrption, the daily dose is 25mg per day versus 12. Dec 15, 2022 · Tianeptine is effective against depression, but off the market in the UK & USA. 🌟 W Dec 12, 2022 · A drug called tianeptine, known colloquially as “gas station heroin,” has been banned by several states. Stay healthy with our scientific information about Tianeptine Sulfate and it's uses. with opioid-like effects. May 9, 2025 · The U. Nausea. How much you take ? Some ppl say if not better is the same, you base it on reports from other people ? They talk about Tianeptine sodium though. Lastly, I believe the equivalent dose of sulfate to sodium is 45mg or something. Jun 14, 2025 · Those brightly colored little bottles actually contain tianeptine, an unapproved drug that can be addictive and carries risks of serious side effects. It is classified as an atypical tricyclic antidepressant and has shown potential benefits in addressing anxiety and irritable bowel disease. Some of the more common brand names include ZaZa, Pegasus, Neptune’s Fix and Tianna Red. We never re-dose or use tia two days in a row or more than twice a week. Has anybody tried the Sulfate form and found it recreational, in any dose ?? Or can it be used to combat WDs since it has long legs compared to sodium ? Reply reply kkkkkkkkk369 • i’ve Oct 16, 2019 · The standard tianeptine dose is 12. Personally, I'm 6 ft, 150 lbs, male, and I take 50 mg of tianeptine sulfate every morning. 5 mg, three times a day. May 13, 2025 · Tianeptine, commonly used to treat depression and anxiety, typically has a dose between 12. Third Party Tested! Aug 10, 2021 · Tianeptine is an antidepressant with opioid effects. Marty Makary. According to a study analyzing Reddit posts about tianeptine, the substance is commonly used to self-treat May 9, 2025 · The Food and Drug Administration (FDA) is warning about the public to stay away from a dietary supplement frequently sold in gas stations and convenience stores across the U. It has been found to have anxiolytic and mood-altering effects. Tianeptine is a substance that does not meet the statutory definition of a dietary ingredient and is an unsafe food additive. It is being falsely marketed and sold in gas stations and online as a dietary supplement. With the sulfate I now dose around 60mg in the morning and another 40mg 4 hours later - that way I get a solid 16 hours with less highs and lows out of it. The updated May 9, 2025 · The FDA is warning the public about "gas station heroin," or products that contain tianeptine, an opioid alternative prescribed as an antidepressant in some countries. Jan 12, 2024 · What are the side effects of tianeptine? At low dosages, common side effects may include headache, dizziness, constipation, dry mouth, drowsiness insomnia, or nightmares. Dry mouth. that is being sold online and in gas stations as a dietary supplement. Unlike other antidepressant agents, tianeptine stimulates the uptake of serotonin (5-hydroxytryptamine; 5-HT) in rat brain synaptosomes and rat and human platelets, increases 5-hydroxyindoleacetic acid (5-HIAA) levels in cerebral tissue and plasma, and If you haven't done Oxy how you know it's better than Oxy lol. Some effects of tianeptine, similar to other commonly used opioid analgesics (e. Tianeptine Sulfate is half the strength of Tianeptine Sodium but it lasts longer than the Sodium form. Recent stories of Tianeptine use have caused health professionals to examine addictive properties of the drug and its potential for harm. Tianeptine Tianep ne, also known as “Gas Sta on Heroin” is not approved by the USA Food and Drug Administra on (FDA) for any medical use. Tianeptine Sulfate: I had a difficult time finding information about recommended dosage for this substance but from a bit of reading I found that the therapeutic dose was between 25-35 mg. 5mg over the usual sodium dosing in a day. The most commonly reported adverse Tianeptine Risks and Side Efects Sometimes referred to as Tianna, Tianeptine sodium powder, Tianna Green, Tianna Red, Tianna White, and Tianeptine sulfate, the drug is considered highly addictive by the FDA. According to recent case Jul 2, 2025 · Additionally, tianeptine has been associated with serious side effects, including withdrawal symptoms and seizures, especially when misused, leading to regulatory restrictions as a controlled substance in several states. poison control centers increased during 2014–2017, suggesting a possible emerging Feb 2, 2024 · The Food and Drug Administration is upping the urgency of its warnings for consumers to avoid purchasing or consuming tianeptine – commonly called “gas station heroin” – a synthetic drug typically sold in tablet or powder form and available for purchase online as well as in convenience stores, gas stations, and smoke shops. poison control centers are reporting a dramatic spike in Feb 2, 2024 · Look for “tianeptine,” “tianeptine sodium” or “tianeptine sulfate” listed in the ingredients or supplement facts. I also have a jar of Tianeptine sulfate (which produces similar nootrotpic\mood boosting effects as the Tianeptine sodium) does anyone have any experience with Tianeptine sulfate at recreational dodges? In order to further explore this drug I definitely want to try it at a higher 'recreational' doses. The guy who runs nootropicsdepot did the math and apparently 45mg Sulfate =~ 37. ” [1] It is illegally marketed in smoke shops, convenience stores, gas stations and online as a dietary supplement, research chemical or brain enhancer. Benefits of taking tianeptine sulfate enhanced mood; anxiolytic effects; decreased impulsivity; enhanced concentration and focus; Sep 27, 2024 · Tianeptine, a non-FDA approved medication that's used to treat depression, poses certain risks. 5mg PO three times daily before meals >70 years old - 12. Tianeptine has found Jan 10, 2024 · Tianeptine is a drug developed by French researchers in the 1960s as an antidepressant. Tianeptine is the most addictive and physically destructive (kidneys especially) drug you can choose. Know about technical details of Tianeptine Sulfate like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at Pharmacompass. Lowest prices! Purchase tianeptine sodium, sulfate, free acid and solution Mar 23, 2020 · What is Tianeptine Sulfate? Tianeptine is a member of the class of drugs known as tricyclic antidepressants (TCAs). Feb 1, 2024 · The US Centers for Disease Control and Prevention is linking a “cluster of severe illness” to products with the unapproved drug tianeptine, also known as “gas station heroin,” that could The FDA and many state health agencies are raising the alarm about tianeptine, also called “gas station heroin. The Centers for Disease Control and Prevention (CDC) reviewed data from 2000 to 2017 from the National Poison Data System (NPDS) of the American Association of Poison Control Centers and noted a rapid and marked increase in tianeptine related calls during this time period. Drowsiness. Tianeptine is highly addictive and when taken in high doses, it acts similarly to opioids, leading to severe withdrawal symptoms, and possibly even death. From prescription drugs to over-the-counter remedies, our drug directory provides valuable insights into uses, side effects, and precautions. Jun 17, 2025 · The U. It’s being marketed as a dietary supplement, but some users are describing it as a Explore the key differences between Tianeptine Sulfate and Tianeptine Sodium. May 14, 2025 · Tianeptine, an opioid commonly referred to as "gas station heroin," is putting public health at risk, according to Food and Drug Commissioner Dr. Tianeptine shows efficacy against serious depressive episodes (major depression), comparable to amitriptyline, imipramine and fluoxetine, but with significantly fewer side effects. Aug 29, 2012 · The dosage of tianeptine should be reduced over 1 to 2 weeks when discontinuing treatment, although there is little evidence of psychological or physical dependence on the drug. The behavioral effects of the antidepressant tianeptine require the mu-opioid receptor. Unsupported claims have been made "I don't think it's a particularly effective drug with a good safety profile compared to what's already available out there," he said. 5mg. Tianeptine Isn?t FDA Approved for Any Medical Use Tianeptine is an unapproved drug in the United States. com you can find out where to buy Tianeptine Sulfate and the best way to take it. I see zero reason to use the sodium version anymore. 5 mg per day, often divided into two or three doses. Sometimes you need a short, strong dose of pain-free energy which, in our case, calls for 40 mg of sodium. 🌟 Aug 10, 2021 · This guide talks about what is tianeptine and how it works including effects, side effects, dose, route of administration, withdrawal, and overdose prevention. It is approved in low doses for that use in many European, Asian and Latin American countries. I know that this dose is currently 12. It is known by various brand names Abstract Tianeptine is a novel antidepressant agent, both structurally (modified tricyclic) and in terms of its pharmacodynamic profile. Tianeptine can be abused and severe withdrawal symptoms can occur when people who are dependent stop taking it. Tianeptine is sold in pills (ZaZa, Tianaa) and powder (Tianeptine sulfate, Tianeptine sodium, or Tianeptine Ethyl Ester). Like other opioids, when stopping use of tianeptine, withdrawal may occur. Tianeptine is an antidepressant drug approved for the treatment of major depressive disorder in countries other than the US. It has the potential to cause adverse The feeling of a large sulfate does is comparable to a low dose of methadone. However, it is important to note that tianeptine is not approved for any use by the United States Federal Drug Administration (FDA Tianeptine is great, I first got the sodium and then switched to sulfate. Oct 20, 2023 · Tianeptine is not approved for any kind of medical use by the US Food and Drug Administration (FDA). May 8, 2025 · The FDA is warning the public about a drug rising in popularity commonly referred to as as "gas station heroin. Structurally, it is classified as a tricyclic antidepressant (TCA), however, it possesses different pharmacological properties than typical tricyclic antidepressants 1. It is the active ingredient in products such as Neptune’s Buy high quality Tianeptine online from a trusted US Vendor. Dizziness. Taking tianeptine can lead to adverse effects and sometimes overdose. Nov 11, 2021 · Tianeptine is an atypical tricyclic drug used as a prescription antidepressant in Europe, Asia and Latin American. Doctors also prescribe Tianeptine to treat asthma and irritable bowel syndrome on occasion. Health care professionals suggested naloxone and other opioid antagonists as treatment for tianep-tine poisoning with documented reports of success. Explore the benefits from Nootropic Sources. Tianeptine sodium ain't got shit on tianeptine sulfate. 5mg every 8 hours and it might be more potent and long lasting. At other times we enjoy about 6 hours of bliss with 100 mg of sulfate. Aug 3, 2019 · Summary What is already known about this topic? Tianeptine is an antidepressant drug that is not approved by the Food and Drug Administration (FDA). I too was curious about it, and for the first 4 months took 50mg 3x per day. Tianeptine Sulfate Capsules are a mood-enhancing supplement designed to promote emotional well-being, mood stability, and mental health. The two primary forms of tianeptine are tianeptine sodium and tianeptine sulfate. To give you an idea of it’s strength, 200 milligrams of Tianeptine Sulfate equals 100 milligrams of Tianeptine Sodium. May 12, 2025 · The U. Tianeptine is a medication approved in some non-US countries for anxiety and depression. 5 mg and 37. 🧠💊 Explore the key differences between Tianeptine Sulfate and Tianeptine Sodium. Common names for tianeptine include “gas station heroin,” “ZaZa Red,” or “Neptune’s Elixir” (among others). 5mg sodium. I actually tossed the rest of the sodium I had after my first few days trying the sulfate and haven't looked back. Because it’s unregulated and sold in dietary supplements, little is known on the purity Getting the correct Tianeptine Sulfate dosage is as important as understanding the science behind Tianeptine Sulfate's benefits and effects. May 13, 2025 · The US Food and Drug Administration has issued a warning about products containing tianeptine, often called “gas station heroin” because of its availability at gas stations. g. When prescribed, tianeptine is typically given at dosages of 12. , morphine, heroin), may include relaxation, euphoria, pain relief, sedation, confusion, drowsiness, dizziness, nausea, vomiting, urinary retention, pupillary constriction, and respiratory depression. These may include: Abdominal pain. While primarily a prescription drug, it is sometimes used in high doses for recreational opioid effects. Any lower is sub-therapeutic. It has a unique and poorly-understood mechanism of action consisting of modulation of the brain's monoaminergic and glutamatergic systems. ” Individuals with an opioid use disorder may be more likely to use tianeptine, as it is inaccurately marketed as a safer alternative to opioids and can have opioid-like Feb 20, 2024 · Coaxil (Tianeptine) Tianeptine, often sold as a medication under the brand name Coaxil and Stablon, stands apart from conventional antidepressants due to its unique properties and mechanism of action. Now, U. Tianeptine Administration Type: Antidepressant Dosage Forms: 12. 5mg PO two times daily before meals Pediatric Dosing N/A Special Populations Pregnancy Rating N/A Lactation risk N/A Renal Dosing Jan 24, 2024 · The US Food and Drug Administration is warning consumers not to purchase or use any tianeptine products, saying it continues to receive reports of severe adverse events, including death, linked to May 13, 2025 · Tianeptine, commonly used to treat depression and anxiety, typically has a dose between 12. com. Jun 3, 2025 · The term “gas station heroin” encompasses the drug tianeptine and other 7-OH drugs with dangerous opioid-like effects, but which may be purchased (for now) at smoke shops, gas stations, and Dec 20, 2019 · What is Tianeptine Sulfate? Full guide on uses, benefits, effects on mood & cognition, proper dosage guide, safety & trusted buying sources! May 12, 2025 · Recognizing tianeptine’s dangerous side effects Medical professionals have documented numerous adverse reactions in tianeptine users that signal its serious health implications. 5 mg, usually 3x a day. Those differences were confirmed by the patient after the prescription of tianeptine sodium. Clinical effects of tianeptine abuse and withdrawal can mimic opioid toxicity and withdrawal. Headache. [19] It was shown to be more effective than maprotiline in a group of people with co-existing depression and anxiety. Self-medication with psychoactive substances Nov 8, 2024 · Discover comprehensive details about Tianeptine, including its pronunciation, uses, dosage instructions, indications, and guidelines on how and when to take it or avoid it. Since Tianeptine Sodium is dosed at 12. 5mg tablet Routes of Administration: Oral Common Trade Names: Coaxil, Stablon Adult Dosing 12. Its unique mechanism of action as a selective serotonin reuptake enhancer is fascinating and can vary considerably from person to person. Food and Drug Administration (FDA) has stepped up warnings about tianeptine, an unapproved antidepressant increasingly sold in gas stations and convenience stores under names like "Zaza Although other countries have approved tianeptine to treat depression and anxiety, some have restricted how tianeptine is prescribed or dispensed, or revised the drug label to warn of possible Mar 29, 2024 · Side effects and withdrawal symptoms Tianeptine can have side effects, even when taken at lower doses. Aug 14, 2020 · In this article, we will cover what tianeptine is, the difference between sodium and salts, method of action, tolerance and addiction potential, and how to dose. ” It can also be obtained online from independent vendors without a prescrip on. Developed by French researchers in the 1960s, Tianeptine offers a departure from the classical treatment of depression in multiple ways - much due to its unique pharmacological profile. " Tianeptine poses a "dangerous and growing health trend Introduction: Tianeptine has recently emerged on the illicit drug market in the United States. Apr 21, 2023 · In the United States, tianeptine, referred to as “gas station heroin,” is an unapproved drug. I don't think you're going to find any scientific research on tianeptine sulfate dosage and body mass, but I'm sure you'll get responses from others about the sodium salt form's research. Learn more about Tianeptine uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Tianeptine. While not approved for . It is also marketed as a dietary supplement, “research chemical,” or nootropic and is listed as an ingredient in some dietary supplement products. CrossRef Google Scholar PubMed Samuels, BA, Nautiyal, KM, Kruegel, AC, et al. Learn about its effects, recommended dosage, and user experiences in this detailed review. Explore its effects, legal status, and abuse potential here. People do get withdrawal symptoms when they ramp up to hundreds of milligrams to a gram per day and then stop. According to the Food and Drug Administration (FDA), companies are Table of Contents What is Tianeptine? Medical Conditions Treated with Tianeptine How Tianeptine Works Dosage and Administration Potential Side Effects Ongoing Research What is Tianeptine? Tianeptine is a unique antidepressant and anxiolytic (anti-anxiety) medication that has been used clinically in Europe, Asia, and South America since the late 1980s [1]. The best Tianeptine dosage is around 8-16 mg, taken 1-3 times daily. Tianeptine (trade names Stablon and Coaxil) is an atypical antidepressant. Constipation. but it has been sold as a dietary supplement under the names “ZaZa” and “Tianaa,” and is widely available over the internet. three times a day it might be doable but it left such a bad impression on me I wouldn't recommend any amount of it to anyone, for anything. This article clarifies their distinct properties, uses, and potential side effects. Food and Drug Administration for any medical use. I titrated up from 25mg once daily to 50mg 3x daily over 2 weeks, and felt no need to increase dosage after that. Learn how the two forms differ, so you can decide which is right for you. Despite that, some companies are illegally marketing and selling products containing tianeptine to consumers. It has made its way to convenience stores and gas sta on shelves, branded as “Zaza” and “Tianna Red. It is classified as an atypical tricyclic antidepressant and has shown potential benefits in addressing anxiety and Tianeptine is a drug used primarily in the treatment of major depressive disorder and has been studied in the treatment of irritable bowel syndrome (IBS) 3. We use both tianeptine sodium and sulfate. And it comes in both powder and pill form. " While this offers advantages for tianeptine over the tricyclic antidepressant agents in terms of dose titration, treatment changes and potential drug interactions, its rapid elimination makes adherence to dosage schedules more important. I tried the sulfate for a couple of weeks and didn't notice much, the sodium maybe provided some small lift after trying it for a month but I was getting more benefit from my MAOI and dropped it. Jul 15, 2023 · Tianeptine is an antidepressant drug approved for the treatment of major depressive disorder in countries other than the US. Hope this helps. Tianeptine appears to afect a person’s opioid receptors, producing symptoms similar to an opioid over-dose. Not only does long-term use of the drug create Shop the highest quality Tianeptine products from Tianeptine Capsules! Tianeptine Sulfate, Free Acid, and more. If taken at the Stablon dose, 12. Food & Drug Administration has issued a warning concerning tianeptine, also known as "gas station heroin," due to its easy access and potential for harm or death. Tianeptine is also known as: Tianeptine sulfate Jul 12, 2018 · Given the role of tianeptine in this patient’s outcome, and its potential for public health impact, an adverse event report has been filed with the Food and Drug Administration. 5 to 50 mg/day; in clinical trials utilizing that therapeutic dose range, tianeptine gave little signal of abuse potential and was generally well tolerated and efficacious for treatment-resistant depression [1, 6, 7]. Jan 12, 2024 · Official answer: Tianeptine is a non-FDA-approved substance sold as a dietary supplement in gas stations and stores under names like Tianeptine is an unapproved drug in the U. Am I setting myself up for disaster? Alright, so I think I can give you probably the best anecdotal piece of information regarding Tianeptine Sulfate's onset of action and duration. Tianeptine use Jun 17, 2025 · What is tianeptine? According to the Mayo Clinic, tianeptine is used in small doses in some countries in Europe and South America to treat symptoms of anxiety, depression and irritable bowel syndrome. Mol Psychiatry 2010; 15: 237–49. Bad dreams. What is added by this report? Tianeptine exposure calls to U. Stay informed and make confident healthcare decisions with our reliable medication guide. With proper dosage schedule, tolerance development to such effects is negligible, but since they can be experienced upon a single administration, the sulfate form of tianeptine is also appropriate for ad hoc use. Common names include “gas station heroin” or “ZaZa Red. Tianeptine overdose fatalities are associated with serum concentrations ranging from 4,000 to 18,000 ng/mL (4). Since tianeptine is not regulated and is easily available in Yep fellow long term therapeutic user here 20mg 2-3x daily sodium Going to try the ethy ester sulfate for the first time Sodium was great with the long duration but was somewhat expensive My ideal dose was 15mg sodium mixed with 20mg sulfate with first thing in the morning with an additional 20mg sulfate in the afternoon I believe if I dose it regularly one of the secondary metabolites (MC5 The body doesn't process and remove the Sulfate as quickly wouldn't it be wise to take it with Milk Thistle or something similar? In general I avoid Tianeptine since it's like a worse version of Tramadol, same effects just weaker and more side effects for me. Navigate our comprehensive drug directory to access detailed information on a wide range of medications. S. At PowderCity. Feb 2, 2023 · Support groups Takeaway Tianeptine, also known as gas station heroin, is an unapproved antidepressant drug in the U. Discover the benefits of tianeptine sulfate. What is Emerging Drug Alert: Tianeptine This notice is to alert substance abuse treatment providers, clinicians, public health agencies and testing labs that Tianeptine, an unapproved atypical antidepressant with opioid activity at higher doses, has been reported for sale in US gas stations and convenience stores, especially throughout the southeast United States. Despite being a tricyclic drug, tianeptine has a significantly different pharmacologic profile than the average TCA and is thought to produce effects through action at several unique receptors. Although other countries have approved tianeptine to treat depression and anxiety, some have restricted how tianeptine is prescribed or dispensed, or revised the drug label to warn of possible addiction. I took a 2 week break, zero withdrawals at all, and now Jul 23, 2025 · The FDA classifies the drug as a substance that does not meet the statutory definition of a dietary ingredient and brands it as an unsafe food additive. The New Jersey Poison Center (NJPIES) has recently identified a cluster of poisoning cases involving tianeptine, a substance with opioid-like effects that is being falsely marketed and sold across the state in gas stations and online as a dietary supplement. I figured that taking 2x 25mg sulfate capsules once daily is what is going to provide the desired therapeutic effect. 🧠💊 Tianeptine, on the other hand, is an analgesic and antidepressant that lacks psychotomimetic side-effects at any sensible dose. 2,3 I tried tianeptine sodium at 12. yfa7 zb z6ju fbaivk avqx cbt3c ebv b1jlj yy7qd akor