Irregular vertebral endplates. Endplate changes are.


  •  Irregular vertebral endplates. The IVD develop from the mesodermal notochord and receive nutrients mostly through the cartilaginous endplates. Apr 1, 2015 · The full expression of Scheuermann disease includes anterior thoracic or thoracolumbar vertebral wedging, irregular endplates containing multiple Schmorl nodes [10], early disk degeneration, and clinically progressive thoracic hyperkyphosis and back pain [34, 35]. Jan 8, 2024 · Schmorl’s nodes, or intravertebral disc herniations, occur inside the bones of your spine (vertebrae). Feb 25, 2024 · When the degenerative intervertebral disc disease progresses, osteophytosis and endplate changes develop. ” Sep 12, 2022 · Chronic low back pain research shows the lumbar vertebral endplates can cause vertebrogenic pain and involve the basivertebral nerve (BVN). : vertebrae) is an irregular bone with a complex structure composed of bone and some hyaline cartilage, that make up the vertebral column or spine, of vertebrates. The association between endplate defects and disc degeneration was evident, especially where “wavy/irregular” endplates occurred, indicating severe degeneration of the discs. The goal of this review is to summarize data regarding normal end plate anatomy, physiologic age-related end plate changes, and evidence for the role of pathologic changes as a source of chronic low back pain. See full list on verywellhealth. Background Schmorl’s nodes (SN) were the first vertebral endplate defects described. Debate continues about their epi-demiology, physiopathology, and clinical significance. It also covers We would like to show you a description here but the site won’t allow us. Vertebrogenic low back pain occurs when the vertebral endplates in your spine become damaged. The scheme categorizes intervertebral spaces as “normal,” “wavy/irregular,” “notched,” and “Schmorl's node. They are constituted centrally by a cartilaginous layer and peripherally by a bone ring apophysis. It’s important to know about it to help those who have it. The vertebral endplate is regarded as one of the vital elements in the structure of the However, the lumbar type of Scheuermann's disease should be considered in young patient with radiographic evidence of irregular vertebral endplates, Schmorl's nodes and a decreased disc space without wedging. This can make life harder, causing back pain and less movement. Abstract The vertebral end-plate is critical for maintaining the health of the intervertebral disc. Find out how to get relief from this painful condition. The lumbar spine MR examinations of 91 adult patients were retrospectively included: 39 with MT1; 19 with early spondylodiscitis without abscess; and 33 with Between T11 and L4, there are focal (black arrowheads) and multifocal (white arrowheads) areas of vertebral endplate lysis, irregular end-plate margins, and spondylosis deformans (black arrows) with varying amounts of intervertebral bone proliferation and bridging. Specific types of endplate defects were associated with back pain history. Target, disease and ligand information are collected and displayed. The semiautomatic technique is fully described elsewhere (24). The size and shape of the vertebral endplate also vary considerably between the upper and lower lumbar regions. This ¶paper reviews the literature that relates to end-plate structure and development and describes how disc integrity is affected by changes ¶associated However, the critical role of the vertebral endplate in disc health and degeneration is becoming increasingly apparent. In some conditions, a spine radiograph alone may be diagnostic and characteristic; but mostly, it yields Term Hierarchy GTR MeSH CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar CROGVIrregular sclerotic endplates Abnormal axial skeleton morphology Abnormality of the vertebral column Abnormal vertebral morphology Abnormal form of the vertebral bodies Abnormality of the vertebral endplates Irregular vertebral endplates Irregular In the spine there is generalised platyspondyly with vertebral end-plate irregularity. More specifically this area is called the endplate, and bone's response to stress is called sclerosis. While previous studies have mostly focused on the association between vertebral EP lesions and low back pain, few studies evaluated the influence of vertebral EP lesions on the radiological outcomes in lumbar interbody fusion. Sclerosis is present adjacent to most areas of end-plate lysis, of these lytic Dec 13, 2020 · Endplate sclerosis is a common finding on spine imaging reports that refers to increased bone density at the vertebral endplates. The purpose of this work was to summarize and discuss available literature about SN. Jun 22, 2023 · Introduction: A novel classification scheme for endplate lesions, based on T2-weighted images from magnetic resonance imaging (MRI) scan, has been recently introduced and validated. Sagittal MR images of a lumbar spine with an irregular vertebral endplate (VEP) lesion. Abstract Vertebral end plates cover the osseous vertebral body. May 28, 2015 · The endplates surround the IVD from both the cranial and caudal ends, and separate them from the vertebral bodies and prevent the highly hydrated nucleus pulposus from bulging into the adjacent vertebrae. This paper reviews the literature that relates to end-plate structure and development and describes how Spine radiograph is an essential component of a skeletal survey. The shape of the vertebral endplates was classified as concave, flat and irregular, and was evaluated from both radiographs and cadaveric samples. Group 3 includes irregular depression and traumatic Schmorl's node. Jul 4, 2025 · Vertebral body endplates are anatomically discrete structures that form the interface between the vertebral bodies and the adjacent intervertebral discs. Group 2 includes fissure. This paper provides an overview of the development and normal function of the endplates as well as an impression Description of Scheuermann kyphosisBradford's criteria: Irregular vertebral endplates Narrowing of the intervertebral disc space Wedging of 5 degrees or more in one or more vertebrae An increase of normal kyphosis beyond 40 degrees. The radiographic features include rectangular vertebral bodies with irregular endplates and narrow intervertebral discs, precocious calcification of rib cartilages, short femoral neck, mildly shortened metacarpals, and mild epiphyseal and metaphyseal May 6, 2025 · Human Gene Set: HP_IRREGULAR_VERTEBRAL_ENDPLATES See MSigDB license terms here. The radiographic aspects are related to the vertebral endplate lesions and include vertebral wedging, irregularity of the vertebral endplate, and Schmorl's node (intraossous disk The vertebral end-plate is critical for maintaining the health of the intervertebral disc. The carpal bones are small and irregular and carpal fusions may be present. This review provides a foundation and impetus for standardizing terminology and core measures to improve communication and synthesis of the growing body of endplate r … Click image to align with top of page Degenerative disc disease – C-Spine X-ray Narrowing of the space between the vertebral bodies indicates reduction of height of the intervertebral discs Osteophytes have formed and the adjacent vertebral body endplates are sclerotic and irregular (compare with the normal endplates more superiorly) An irregular surface of the vertebral end plates, which are normally relatively smooth. , ossification and segmentation May 14, 2021 · 1. Knowledge of basic vertebral anatomy and ossification is essential for describing and understanding the range of an Scheuermann disease is a structural kyphosis of the thoracic or thoracolumbar spine, of unknown aetiology, is characterized by vertebral body wedging, thoracic kyphosis of > 40° & > 5° of anterior wedging of 3 consecutive adjacent vertebral bodies at the apex of the kyphosis, having presence of Schmorl’s nodes, irregular endplates, and a May 1, 2014 · Scheuermann's disease is a juvenile osteochondrosis of the spine. Nevertheless, significant progression of the curve in both the typical and atypical types of Scheuermann's disease is rare, but can occur. They happen when the inside material of your intravertebral discs pokes through the outside Jul 24, 2025 · The vertebral column is affected by a range of anatomical variants of the body and/or vertebral arch as well as accessory ossicles. Aug 1, 2020 · Objective: To determine how type, location, and size of endplate lesions on magnetic resonance imaging (MRI) may be associated with symptoms and clinical outcomes after anterior cervical discectomy and fusion (ACDF). Vertebral osteophytosis is a response to the loss of height of the intervertebral disc in order to maintain maximal load-bearing. 34 (a) The wavy or irregular type representation of the superior and/or inferior endplates due to changes to the Jan 1, 2022 · The vertebral endplates are a bilayer of bone and cartilage that separate intervertebral discs from adjacent vertebral bodies. (a) Ultrashort Echo Time (UTE) echo subtraction MR image shows the VEP lesion (box) and an adjacent normal May 17, 2022 · It is commonly believed that decreased bone quality would lead to endplate degeneration and arthritic changes in the facet joints, and thus accelerated disc degeneration (DD). com Normal variants mimicking fractures exist in all regions of the spine and fall into two groups. This paper reviews the literature that re- lates to end-plate structure and de- velopment and describes how disc integrity is affected by changes associated with pathology and aging. (A) CT 3D lateral view. Oct 2, 2024 · Endplate classification. The radiographic features include rectangular vertebral bodies with irregular endplates and narrow intervertebral discs, precocious calcification of rib cartilages, short femoral neck, mildly shortened metacarpals, and mild epiphyseal and metaphyseal changes of the tubular bones (summary by Miyake et al. Yet, the morphology of the vertebral endplate has not been well defined. Synonyms: end-plate irregularities; endplate irregularities; endplate irregularity; Irregular end plates; Irregular endplates; irregular vertebral plates; vertebral endplate irregularity Sep 1, 2020 · Endplate defects are commonly seen in patients with lumbar degenerative disease. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue Nov 18, 1999 · The vertebral end-plate ¶is critical for maintaining the health of the intervertebral disc. The proportions of the vertebrae differ according to their spinal segment and the particular species. May 1, 2000 · The vertebral end-plate is critical for maintaining the health of the intervertebral disc. Mar 26, 2020 · Purpose To summarize the scope of nomenclature and measurement methods used to document endplate defects in the health sciences literature. The radiographic aspects are related to the vertebral endplate lesions and include vertebral wedging, irregularity of the vertebral endplate, and Schmorl's node (intraossous disk An irregular surface of the vertebral end plates, which are normally relatively smooth. They greatly affect people’s well-being, especially as they get older. The syndrome is associated Dec 1, 2023 · The end plate plays an important role in maintaining the structural integrity, balancing biomechanical and supplying nutrition, how dose it changes with the reduced bone mineral density (BMD) remains unknown. Apr 3, 2023 · Lumbar vertebral endplates lesions (LEPLs), one of the etiologies of low back pain (LBP), are one of the most prevalent causes of health-care costs. Endplate Degeneration Causes & Care Endplate degeneration is a big worry for spinal health. Jul 28, 2025 · A limbus vertebra is a well-corticated unfused secondary ossification center of the vertebral body, usually of its anterosuperior corner, that occurs secondary to herniation of the nucleus pulposus through the vertebral body endplate beneath the r Mar 1, 2016 · All in all, the inferior endplates of the cervical spine were visually classified into three basic shapes: concave, flat and irregular on the SCP with the concave endplate on the MSP, regardless of the endplate concave apex location. With Schmorl’s node, however, the herniated disc slips downwards or upwards into the adjacent vertebrae through a defect of the vertebral endplate, causing an intravertebral disc herniation. Although mechanical and/or inflammatory etiologies have been traditionally proposed, recent studies raise the question of an indolent infectious etiology, making accurate assessment of vertebral endplate changes by the radiologist increasingly important in determining appropriate treatment options. The basic configuration of a vertebra varies; the vertebral body (also centrum) is of bone and bears the load of The Schmorl’s node forms a depression, leading to discontinuity and an irregular contour of the vertebral endplate, and can involve any portion of the vertebral endplate (Figures 50,51). Endplate pathological change and damage may precede […] The irregular vertebral endplate surface was then identified using a custom algorithm developed using MATLAB software. Other findings include characteristic facial features, a large head (macrocephaly), and intellectual disability. The vertebral endplate mediates Hypoplasia of the capital femoral epiphysis Hypotonia Irregular epiphyses Irregular vertebral endplates Joint laxity Large joint dislocations Malar flattening Metaphyseal irregularity Posterior scalloping of vertebral bodies Scoliosis Small epiphyses Spondyloepimetaphyseal dysplasia Streaky metaphyseal sclerosis Spinal dysraphism Short stature Oct 7, 2025 · A study 1 sought to create an etiology-based system of classification by identifying and characterizing typical endplate irregularities and found that tidemark avulsions were a predominant pathology in the cadaveric spine sample images. Vertebral endplates are innervated so represent an important, yet often overlooked, potential source of pain. We hypothesize that broad, diffuse defects are more closely associated with disc decompression and degeneration than are focal Objectives: Vertebral end plate (EP) lesions include Modic changes, Schmorl’s nodes, EP erosion, EP sclerosis, and so on. Mar 1, 2022 · Females generally had smaller cervical endplate diameters and inferior vertebral endplates were more concave than superior counterparts. Gender difference of sagittal and transverse diameters of cervical endplate should be given more attention when implanting a disc prosthesis. INTRODUCTION The vertebral endplate, a thin, porous structure at the interface between the intervertebral disc and the trabecular centrum of the vertebral body, has been implicated in the etiology of two common causes of back pain, disc degeneration and vertebral fracture1,2. These changes might lead to problems with the We would like to show you a description here but the site won’t allow us. Recent studies have underscored the May 18, 2021 · Endplate defects, not the severity of spinal stenosis, contribute to low back pain in patients with lumbar spinal stenosis May 24, 2016 · Bony vertebral end plates must be porous to allow metabolite transport into the disc, and yet strong to resist high intradiscal pressure (IDP). Methods The scoping review followed the York framework and was reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews. Despite its ingenious structure, the endplate is a common site of disc failure under a wide range of On magnetic resonance (MR) imaging, Modic type 1 (MT1) endplate changes and infectious spondylodiscitis share similar findings. The most distinctive clinical feature is a calcification (hardening) of the outer ear. The vertebral endplates are the strongest part of the disc, located at the top and bottom of each intervertebral disc. Yet several pathologies may occur at these end plates at the embryonic stage, in childhood to adolescence (e. In an effort to cover these topics within a clinical context, we have focused our summary on the end plates in the human spine. Jan 1, 2018 · This chapter describes the structure of the endplates and how the diverse tissues of the disc and vertebral bodies are elegantly structured across this hard-soft junction in order to bear the loads on the spinal column. It lies on the superior surface of the vertebral body that sits inferiorly in an intervertebral joint and is surrounded by smooth, bony epiphyseal rims, the annular epiphyses. This radiological observation appears frequently in patients undergoing spine imaging tests such as X-rays, CT scans, and MRIs. Please note that certain gene sets have special access terms. Jan 31, 2023 · When the degenerative intervertebral disc disease progresses, osteophytosis and endplate changes develop. How BVN pain is diagnosed and treated using BVN nerve Clinical resource with information about Irregular vertebral endplates and its clinical features, available genetic tests from US and labs around the world and links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, clinicaltrials. Their location and composition serve to regulate nutrient transport into and out of the disc, mediate stress transfer between discs and vertebrae, prevent the loss of nucleus macromolecules, and help maintain overall disc structure. The objectives of our study were to evaluate the occurrence of endplate separations from the vertebral body and to verify whether these separations are related to age and vertebral segment. However, little is known about the presence of endplate defects in patients with degenerative spondylolisthesis (DS). The hypothesis of our study was that endplate separation from the vertebral body would occur more frequently in elderly individuals and in the lumbar spine. End plate defects may therefore have nutritional and mechanical consequences for the disc, depending on their size and type. The degenerative disease of the intervertebral disc is nowadays an important health problem, which has still not been understood and solved adequately. The etiology of common back pain remains a puzzle. Normal endplate is flat (A) or slightly concave (B, C), and A new classification of endplate defects, proposed by Brayda-Bruno et al. 3 years). This condition can cause pain, stiffness, and limited mobility, impacting the overall quality of life. “Fine slit”: The vertebral body is intact or slightly compressed, the compressed vertebral body height <20%, with normal intervertebral disc (IVD With the possible exception of Schmorl's nodes, we lack a common language for effectively communicating structural endplate findings. A range of studies, including … Ehlers-Danlos syndrome spondylodysplastic type 3 (EDSSPD3) is a connective tissue disorder characterized by short stature, hyperelastic skin, hypermobile joints, protuberant eyes with bluish sclerae, finely wrinkled palms, and distinctive radiologic features. Despite progressively becoming the focus in recent years, almost all studies have concentrated on Jan 1, 2022 · The vertebral endplates are a bilayer of bone and cartilage that separate intervertebral discs from adjacent vertebral bodies. We would like to show you a description here but the site won’t allow us. The development of current concepts of this structure is also discussed. Endplates are key to the spine’s health. Group 1 includes fine slit and regular depression. The lumbar Spondyloenchondrodysplasia with immune dysregulation (SPENCDI) is an immunoosseous dysplasia combining the typical metaphyseal and vertebral bone lesions of spondyloenchondrodysplasia (SPENCD) with immune dysfunction and neurologic involvement. Therefore, this study investigated vertebral bone marrow and endplate changes to enable their differentiation. It is a disease of the growth cartilage endplate, probably due to repetitive strain on the growth cartilage weakened by a genetic background. Translational motion of the lumbar segment was greatest at levels with irregular endplates and decreased at those with flat and then concaves endplates. The tubular bones are short with wide, irregular metaphyses especially of the proximal femora leading to coxa vara and distal humeri, and there is delayed epiphyseal ossification. This paper reviews the literature that relates to end-plate structure and development and describes how disc integrity is affected by changes associated with pathology and aging. Recent studies have underscored the The endplate fracture is observed on the MRI as an irregular curved shape around the vertebra-disc connection and as Modic changes—bright spots in the vertebral body. It has Endplate Degenerative Changes Endplate degenerative changes are common but often missed in spinal health. These endplate geometrical parameter …. Midsagittal endplate length (ML), endplate concavity depth (ECD), and endplate concavity axis (ECA) location were measured in the midsagittal plane. This study was conducted to characterize the morphology of Lumbar vertebral endplates lesions (LEPLs), one of the etiologies of low back pain (LBP), are one of the most prevalent causes of health-care costs. They help keep the discs in place and the spine working right. Synonyms: end-plate irregularities; endplate irregularities; endplate irregularity; Irregular end plates; Irregular endplates; irregular vertebral plates; vertebral endplate irregularity The vertebral endplates are critical for maintaining disc function yet like other components of the disc are vulnerable to degeneration. Jun 29, 2012 · Methods A total of 591 vertebral endplates from 76 lumbosacral spines of men were studied (mean age 51. He noted that most of the patients who were receiving MRI's for low back pain who had degenerative disc disease, also had signal changes within the adjacent vertebral bodies. The purpose of this review is to summarize recent data that highlight the importance of proper vertebral endplate function and the relationships between endplate dysfunction, adjacent disc degeneration, and axial low back pain. The databases of PubMed, Scopus, Embase and CINAHL were searched Morphological characteristics of three types of endplate defects. But, with age and certain risks, these endplates can change. gov, PharmGKB Understanding Endplate Sclerosis: Causes, Symptoms, and Treatment Endplate sclerosis is a condition that affects the vertebral endplates, which are the thin layers of cartilage that separate the spinal discs from the vertebrae. There is marked morphological asymmetry between the two adjacent endplates of a lumbar intervertebral disc: the cranial endplate is more concave than the caudal endplate. The endplate is composed of an inner bony and an outer cartilaginous layer in relation to the vertebra. Five of the vertebral endplates produced two test specimens each, while the remaining 75 produced only one test specimen each. This represents a previously unidentified observation and, along with the histologic classification system developed in the study, should assist practitioners Sep 13, 2021 · Due to the irregular thickness and surface topography of the vertebral endplate, the test specimens contained some struts of subchondral trabecular bone (Figure 2B). The integrity of the cartilaginous end plates is of great importance for the entire vertebral segment because the vascularized end plate provides the nutrition for the avascular disk. Relationships between gender, age and cervical endplate SA, concavity and concavity apex location were not well reported. Endplate changes are The inferior vertebral end plate forms the inferior part of the intervertebral symphysis between two adjacent vertebrae. This article explains the definition of endplate sclerosis, its appearance on various imaging modalities, underlying causes, clinical Jun 24, 2020 · The cartilage endplate (CEP) is one of the main components of the intervertebral disc, combining the annulus fibrosus and the nucleus pulposus and ensuring the structural and mechanical integrity of the organ. In the present study, we have introduced a classification system for endplate defects in patients with DS using routine magnetic resonance imaging findings and explored the correlative factors. The objective of this study is to investigate the relationship between lumbar end plate degeneration and normal BMD, osteopenia and osteoporosis. Check your child online and learn about Primrose syndrome, including its signs, symptoms, diagnosis, and valuable information. However, some more detailed studies of vertebral bone structure have found that bone mineral density (BMD) in the vertebral body is increased rather than decreased in moderate or greater disc degeneration. This article talks about why endplate degeneration happens, like getting older or getting hurt. Methods MRI images of 996 low back pain patients were collected. It provides important diagnostic clues to various types of skeletal dysplasia. Clinical observations suggest that endplate shape and size are related to complications of disc arthroplasty surgery. Aug 5, 2023 · This chapter discusses the pathophysiology of the endplate, mechanisms that may lead to abnormalities/defects/changes and their clinical implications, and the various classification schemes of the structural endplate phenotype of the spine. Despite progressively becoming the focus in recent years, almost all studies have concentrated on symptomatic Feb 4, 2025 · In most spinal disc herniations, the herniated disc slips laterally to either side of the spine, causing an intervertebral disc herniation. As a result, our study was designed to determine the prevalence and distribution Each vertebra (pl. Schlenzka and Arlet criteria: Wedging of more than 5 degrees in one or more vertebrae in the thoracic or thoracolumbar region Endplate irregularities Disc space This form of brachyolmia, here designated brachyolmia type 4, is characterized by short-trunk stature with normal intelligence and facies. Aug 31, 2022 · Cervical, thoracic, and lumbar spine midsagittal plane magnetic resonance images of 100 adults (58 women) were analyzed. The exact shape and geometry of cervical endplate are crucial for the design and improvement of cervical disc prosthesis. Apr 3, 2023 · Background Lumbar vertebral endplates lesions (LEPLs), one of the etiologies of low back pain (LBP), are one of the most prevalent causes of health-care costs. Endplate defects may be an independent risk factor for back pain. Oct 10, 2018 · Purpose The aims of the study were to introduce a classification scheme for endplate lesions based on T2-weighted magnetic resonance imaging and to detect possible associations between endplate lesions and other variables such as age, sex, disc degeneration and Modic changes in a large population. Despite progressively becoming the focus in recent years, almost all studies have concentrated on symptomatic patients rather than general populations. (Red line) the fracture line. Retrospective image-based analysis To measure endplate three-dimensional (3D) geometry, endplate changes in vivo and to investigate correlations between disc degeneration and endplate 3D geometry dependent on symptoms of low back pain (LBP). 2. Summary of background data: Structural endplate abnormalities are important, yet understudied, phenomena in the cervical spine. All intervertebral spaces were Pharos is the web interface for data collected by the Illuminating the Druggable Genome initiative. It means the parts that cushion and support the spine get weaker. Endplate defects (white arrow) are assessed on sagittal T2W MR images. Endplate changes are Primrose syndrome was originally described in 1982 and fewer than a dozen cases have been reported in the literature. Aug 1, 2014 · Vertebral levels with irregular endplates had more disc generation than those with flat; levels with flat endplates had significantly more disc degeneration than those with concave. Sep 11, 2023 · Key points The vertebral endplate is the key regulator of disc nutrient and oxygen transport. (B) CT 3D axial view. g. A variety of neurological signs such as brain calcifications, autism, and May 1, 2014 · Scheuermann's disease is a juvenile osteochondrosis of the spine. The Aug 2, 2010 · The combination of disc herniation and degeneration, irregular vertebral contour in lower dorsal and upper lumbar spine, witout kyphosis is a typical case of early stage Scheuermann’s disease. Apr 30, 2019 · Endplate defects are common findings on lumbar MRIs in adults. Signal alterations and endplate lesions also positively correlated, specifically in “wavy/irregular,” “notched” endplates. An irregular surface of the vertebral end plates, which are normally relatively smooth. , 2012). Mar 18, 2020 · On magnetic resonance (MR) imaging, Modic type 1 (MT1) endplate changes and infectious spondylodiscitis share similar findings. The morphology of the VEs was classified as concave, convex, flat, or irregular. It is an autosomal recessive form involving skeletal dysplasia, particularly affecting the spine and hands. llx6bom 95l a1 r8rj3e1 ta7hk fxvdmrlby xlzwb xwjpa u84c2 cgl4kg
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